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Positive data reported for eptinezumab in Sunrise trial New insights on treatment holidays with erenumab Dual CGRP ligand mAb and gepant therapy reduces headache severity CGRP-mAb switching yields migraine day reduction Lower switching rates with atogepant than CGRP mAbs EMBRACE shows erenumab reduces migraine severity Older patients benefit from CGRP mAbs too DELIVER shows long term QoL benefits with eptinezumab

Fremanezumab

Fremanezumab

In September 2018, Ajovy (fremanezumab) became the second CGRP monoclonal antibody to be approved for the prevention of migraine in adults, and the first and only anti-CGRP therapy with monthly and quarterly dosing options. Approval was supported by data including results of two large Phase 3 clinical trials, one in episodic migraine and the other in chronic migraine. The subsequent Phase 3b FOCUS trial investigated fremanezumab in patients with an inadequate response to 2-4 previous preventive therapies.

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