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Positive data reported for eptinezumab in Sunrise trial New insights on treatment holidays with erenumab Dual CGRP ligand mAb and gepant therapy reduces headache severity CGRP-mAb switching yields migraine day reduction Lower switching rates with atogepant than CGRP mAbs EMBRACE shows erenumab reduces migraine severity Older patients benefit from CGRP mAbs too DELIVER shows long term QoL benefits with eptinezumab

Rimegepant

Rimegepant

In February 2020, Nurtec ODT (rimegepant) became the second oral CGRP receptor antagonist (gepant) to be approved for the acute treatment of migraine in adults. Rimegepant is formulated as a fast-acting orally disintegrating tablet (ODT), and its approval was supported by data including results of the Phase 3 Study 303 of rimegepant ODT, and additional clinical trials of rimegepant tablet including Study 301 and Study 302.

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