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Positive data reported for eptinezumab in Sunrise trial New insights on treatment holidays with erenumab Dual CGRP ligand mAb and gepant therapy reduces headache severity CGRP-mAb switching yields migraine day reduction Lower switching rates with atogepant than CGRP mAbs EMBRACE shows erenumab reduces migraine severity Older patients benefit from CGRP mAbs too DELIVER shows long term QoL benefits with eptinezumab

Ubrogepant

Ubrogepant

In December 2019, Ubrelvy (ubrogepant) became the first oral CGRP receptor antagonist (gepant) to be approved for the acute treatment of migraine in adults. Approval was supported by data including the results of two Phase 3 clinical trials, ACHIEVE 1 and 2 of ubrogepant in the acute treatment of migraine. A Phase 1 trial demonstrated the tolerability and safety of intermittent, high frequency dosing of ubrogepant.

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