Reports from this year’s annual scientific meeting of the American Headache Society in San Diego, USA, and online (13-16 June 2024), include recent progress towards precision medicine for migraine, concerning data about patient groups that miss out on anti-CGRP therapies, CGRP mAb trial results in cluster headache, and cortical changes following CGRP mAb therapy.
A machine learning model developed by researchers at a US tertiary headache centre can accurately predict response to CGRP mAbs nearly 80% of the time. A deep neural network, TabNet, was trained using 145 variables based on results of questionnaires completed by 4260 adult patients with migraine during their initial and follow up headache consultations …
Read more »Eptinezumab did not reduce the frequency of episodic cluster headache (eCH) in the two weeks after treatment but improvements were seen in weekly ≥50% responder rates and patient-perceived disease improvement. These were the main findings of the Phase 3, placebo controlled ALLEVIATE trial (NCT04688775) of eptinezumab 400 mg i.v in 231 patients with eCH.1 Over …
Read more »Women and Hispanic patients with chronic migraine, and those living in some poorer areas, missed out on CGRP mAb and gepant prescriptions during roll-out at a large US migraine centre, according to results of a retrospective cohort study using data adapted from the Stanford deidentified instance of the Observational Medical Outcomes Partnership Common Data Model …
Read more »Reductions in cortical thickness and decreased functional connectivity seen in patients with migraine who respond to CGRP mAbs may indicate recovery from maladaptive neural activity in the visual, sensory and pain regions and normalisation of the hyperreactive/hyperexcitable state seen in migraine. This was the conclusion of Dr Edina Szabo from Beth Israel Deaconess Medical Center …
Read more »Macrophages and inducible nitric oxide synthase (iNOS) may contribute to the downstream effects of CGRP in migraine, according to results of a preclinical study of the impact of depleting macrophages and inhibiting iNOS prior to dural treatment with CGRP. In the study, intraperitoneal injections of clodronate liposomes (150 μL, IP) to deplete macrophages, or the …
Read more »Real world pregnancy registers have been established for fremanezumab, ubrogepant and atogepant, and interim data are reassuring.1,2 The fremanezumab migraine registry was established in the USA in 2020 (www.tevamigrainepregnancyregistry.com) and, as of 28 April 2023, 12 patients were enrolled – 10 in the fremanezumab cohort (nine prospective and one retrospective) and 2 in comparison group …
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Financial support was provided as GMG Knowledge Gap Grant from Pfizer Inc, Pfizer have provided only financial support and had no input into the content provided.
